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Prediction of genome-wide effects of single nucleotide variants on transcription factor binding

Single nucleotide variants (SNVs) located in transcriptional regulatory regions can result in gene expression changes that lead to adaptive or detrimental phenotypic outcomes. Here, we predict gain or loss of binding sites for 741 transcription factors (TFs) across the human genome. We calculated ‘g...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Carrasco Pro, Sebastian, Bulekova, Katia, Gregor, Brian, Labadorf, Adam, Fuxman Bass, Juan Ignacio
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7572467/
https://ncbi.nlm.nih.gov/pubmed/33077858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-74793-4
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