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Ebselen, Disulfiram, Carmofur, PX-12, Tideglusib, and Shikonin Are Nonspecific Promiscuous SARS-CoV-2 Main Protease Inhibitors
[Image: see text] Among the drug targets being investigated for SARS-CoV-2, the viral main protease (M(pro)) is one of the most extensively studied. M(pro) is a cysteine protease that hydrolyzes the viral polyprotein at more than 11 sites. It is highly conserved and has a unique substrate preference...
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| Publicado no: | ACS Pharmacol Transl Sci |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American
Chemical Society
2020
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7571300/ https://ncbi.nlm.nih.gov/pubmed/33330841 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.0c00130 |
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