Structure and inhibition of the SARS-CoV-2 main protease reveals strategy for developing dual inhibitors against M(pro) and cathepsin L

The main protease (M(pro)) of SARS-CoV-2, the pathogen responsible for the COVID-19 pandemic, is a key antiviral drug target. While most SARS-CoV-2 M(pro) inhibitors have a γ-lactam glutamine surrogate at the P1 position, we recently discovered several M(pro) inhibitors have hydrophobic moieties at...

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Détails bibliographiques
Publié dans:bioRxiv
Auteurs principaux: Sacco, Michael Dominic, Ma, Chunlong, Lagarias, Panagiotis, Gao, Ang, Townsend, Julia Alma, Meng, Xiangzhi, Dube, Peter, Zhang, Xiujun, Hu, Yanmei, Kitamura, Naoya, Hurst, Brett, Tarbet, Bart, Marty, Michael Thomas, Kolocouris, Antonios, Xiang, Yan, Chen, Yu, Wang, Jun
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7402059/
https://ncbi.nlm.nih.gov/pubmed/32766590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.07.27.223727
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