Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M(pro) and cathepsin L

The main protease (M(pro)) of SARS-CoV-2 is a key antiviral drug target. While most M(pro) inhibitors have a γ-lactam glutamine surrogate at the P1 position, we recently found that several M(pro) inhibitors have hydrophobic moieties at the P1 site, including calpain inhibitors II and XII, which are...

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محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:Sci Adv
المؤلفون الرئيسيون: Sacco, Michael Dominic, Ma, Chunlong, Lagarias, Panagiotis, Gao, Ang, Townsend, Julia Alma, Meng, Xiangzhi, Dube, Peter, Zhang, Xiujun, Hu, Yanmei, Kitamura, Naoya, Hurst, Brett, Tarbet, Bart, Marty, Michael Thomas, Kolocouris, Antonios, Xiang, Yan, Chen, Yu, Wang, Jun
التنسيق: Artigo
اللغة:Inglês
منشور في: American Association for the Advancement of Science 2020
الموضوعات:
Research Articles
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC7725459/
https://ncbi.nlm.nih.gov/pubmed/33158912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abe0751
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