লোডিং...
Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M(pro) and cathepsin L
The main protease (M(pro)) of SARS-CoV-2 is a key antiviral drug target. While most M(pro) inhibitors have a γ-lactam glutamine surrogate at the P1 position, we recently found that several M(pro) inhibitors have hydrophobic moieties at the P1 site, including calpain inhibitors II and XII, which are...
সংরক্ষণ করুন:
| প্রকাশিত: | Sci Adv |
|---|---|
| প্রধান লেখক: | , , , , , , , , , , , , , , , , |
| বিন্যাস: | Artigo |
| ভাষা: | Inglês |
| প্রকাশিত: |
American Association for the Advancement of Science
2020
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| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7725459/ https://ncbi.nlm.nih.gov/pubmed/33158912 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abe0751 |
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