Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M(pro) and cathepsin L

The main protease (M(pro)) of SARS-CoV-2 is a key antiviral drug target. While most M(pro) inhibitors have a γ-lactam glutamine surrogate at the P1 position, we recently found that several M(pro) inhibitors have hydrophobic moieties at the P1 site, including calpain inhibitors II and XII, which are...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Sci Adv
Autors principals: Sacco, Michael Dominic, Ma, Chunlong, Lagarias, Panagiotis, Gao, Ang, Townsend, Julia Alma, Meng, Xiangzhi, Dube, Peter, Zhang, Xiujun, Hu, Yanmei, Kitamura, Naoya, Hurst, Brett, Tarbet, Bart, Marty, Michael Thomas, Kolocouris, Antonios, Xiang, Yan, Chen, Yu, Wang, Jun
Format: Artigo
Idioma:Inglês
Publicat: American Association for the Advancement of Science 2020
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7725459/
https://ncbi.nlm.nih.gov/pubmed/33158912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abe0751
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars