Anti-leukemic effect of CDK9 inhibition in T-cell prolymphocytic leukemia

T-cell prolymphocytic leukemia (T-PLL) is an aggressive malignancy characterized by chemotherapy resistance and a median survival of less than 2 years. Here, we investigated the pharmacological effects of the novel highly specific cyclin-dependent kinase 9 (CDK9) inhibitor LDC526 and its clinically...

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Publicat a:Ther Adv Hematol
Autors principals: Johansson, Patricia, Dierichs, Laura, Klein-Hitpass, Ludger, Bergmann, Anke K., Möllmann, Michael, Menninger, Sascha, Habenberger, Peter, Klebl, Bert, Siveke, Jens T., Dührsen, Ulrich, Choidas, Axel, Dürig, Jan
Format: Artigo
Idioma:Inglês
Publicat: SAGE Publications 2020
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7570784/
https://ncbi.nlm.nih.gov/pubmed/33117517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2040620720933761
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