RasGRP1 induces autophagy and transformation-associated changes in primary human keratinocytes

Ras mutations are present in only a subset of sporadic human cutaneous squamous cell carcinomas (cSCC) even though Ras is activated in most. This suggests that other mechanisms of Ras activation play a role in the disease. The aberrant expression of RasGRP1, a guanyl nucleotide exchange factor for R...

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Bibliografiske detaljer
Udgivet i:Transl Oncol
Main Authors: Fonseca, Lauren L., Yang, Won Seok, Geerts, Dirk, Turkson, James, Ji, Junfang, Ramos, Joe W.
Format: Artigo
Sprog:Inglês
Udgivet: Neoplasia Press 2020
Fag:
Original article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7569238/
https://ncbi.nlm.nih.gov/pubmed/33074128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2020.100880
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