Aß40 displays amyloidogenic properties in the non-transgenic mouse brain but does not exacerbate Aß42 toxicity in Drosophila

BACKGROUND: Self-assembly of the amyloid-β (Aβ) peptide into aggregates, from small oligomers to amyloid fibrils, is fundamentally linked with Alzheimer’s disease (AD). However, it is clear that not all forms of Aβ are equally harmful and that linking a specific aggregate to toxicity also depends on...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Alzheimers Res Ther
Main Authors: De Mena, Lorena, Smith, Michael A., Martin, Jason, Dunton, Katie L., Ceballos-Diaz, Carolina, Jansen-West, Karen R., Cruz, Pedro E., Dillon, Kristy D., Rincon-Limas, Diego E., Golde, Todd E., Moore, Brenda D., Levites, Yona
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2020
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7568834/
https://ncbi.nlm.nih.gov/pubmed/33069251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-020-00698-z
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