CtIP-mediated DNA resection is dispensable for IgH class switch recombination by alternative end-joining

To generate antibodies with different effector functions, B cells undergo Immunoglobulin Heavy Chain (IgH) class switch recombination (CSR). The ligation step of CSR is usually mediated by the classical nonhomologous end-joining (cNHEJ) pathway. In cNHEJ-deficient cells, a remarkable ∼25% of CSR can...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Wang, Xiaobin S., Zhao, Junfei, Wu-Baer, Foon, Shao, Zhengping, Lee, Brian J., Cupo, Olivia M., Rabadan, Raul, Gautier, Jean, Baer, Richard, Zha, Shan
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2020
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7568320/
https://ncbi.nlm.nih.gov/pubmed/32989150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2010972117
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