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CtIP promotes microhomology-mediated alternative end-joining during class switch recombination
Immunoglobulin heavy chain (Igh) class switch recombination (CSR) requires targeted introduction of DNA double strand breaks (DSBs) into repetitive “switch” region DNA elements in the Igh locus and subsequent ligation between distal DSBs. Both canonical non-homologous end-joining (C-NHEJ) that seals...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3471154/ https://ncbi.nlm.nih.gov/pubmed/21131982 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1942 |
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