Targeting pyrimidine synthesis accentuates molecular therapy response in glioblastoma stem cells

Glioblastoma stem cells (GSCs) reprogram glucose metabolism by hijacking high-affinity glucose uptake to survive in a nutritionally dynamic microenvironment. Here, we trace metabolic aberrations in GSCs to link core genetic mutations in glioblastoma to dependency on de novo pyrimidine synthesis. Tar...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:Sci Transl Med
Hoofdauteurs: Wang, Xiuxing, Yang, Kailin, Wu, Qiulian, Kim, Leo J.Y., Morton, Andrew R., Gimple, Ryan C., Prager, Briana C., Shi, Yu, Zhou, Wenchao, Bhargava, Shruti, Zhu, Zhe, Jiang, Li, Tao, Weiwei, Qiu, Zhixin, Zhao, Linjie, Zhang, Guoxing, Li, Xiqing, Agnihotri, Sameer, Mischel, Paul S., Mack, Stephen C., Bao, Shideng, Rich, Jeremy N.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
Onderwerpen:
Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7568232/
https://ncbi.nlm.nih.gov/pubmed/31391321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aau4972
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items