Targeting pyrimidine synthesis accentuates molecular therapy response in glioblastoma stem cells

Glioblastoma stem cells (GSCs) reprogram glucose metabolism by hijacking high-affinity glucose uptake to survive in a nutritionally dynamic microenvironment. Here, we trace metabolic aberrations in GSCs to link core genetic mutations in glioblastoma to dependency on de novo pyrimidine synthesis. Tar...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Wang, Xiuxing, Yang, Kailin, Wu, Qiulian, Kim, Leo J.Y., Morton, Andrew R., Gimple, Ryan C., Prager, Briana C., Shi, Yu, Zhou, Wenchao, Bhargava, Shruti, Zhu, Zhe, Jiang, Li, Tao, Weiwei, Qiu, Zhixin, Zhao, Linjie, Zhang, Guoxing, Li, Xiqing, Agnihotri, Sameer, Mischel, Paul S., Mack, Stephen C., Bao, Shideng, Rich, Jeremy N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7568232/
https://ncbi.nlm.nih.gov/pubmed/31391321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aau4972
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