Platelet Factor 4 Interactions with Short Heparin Oligomers: Implications for Folding and Assembly

Association of platelet factor 4 (PF4) with heparin is a first step in formation of aggregates implicated in the development of heparin-induced thrombocytopenia (HIT), a potentially fatal immune disorder affecting 1–5% of patients receiving heparin. Despite being a critically important element in HI...

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Vydáno v:Biophys J
Hlavní autoři: Niu, Chendi, Yang, Yang, Huynh, Angela, Nazy, Ishac, Kaltashov, Igor A.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7567982/
https://ncbi.nlm.nih.gov/pubmed/32348723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2020.04.012
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