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Platelet Factor 4 Interactions with Short Heparin Oligomers: Implications for Folding and Assembly

Association of platelet factor 4 (PF4) with heparin is a first step in formation of aggregates implicated in the development of heparin-induced thrombocytopenia (HIT), a potentially fatal immune disorder affecting 1–5% of patients receiving heparin. Despite being a critically important element in HI...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Biophys J
Main Authors: Niu, Chendi, Yang, Yang, Huynh, Angela, Nazy, Ishac, Kaltashov, Igor A.
Format: Artigo
Jezik:Inglês
Izdano: The Biophysical Society 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7567982/
https://ncbi.nlm.nih.gov/pubmed/32348723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2020.04.012
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