Dissecting Dynamic and Hydration Contributions to Sequence-Dependent DNA Minor Groove Recognition

Sequence selectivity is a critical attribute of DNA-binding ligands and underlines the need for detailed molecular descriptions of binding in representative sequence contexts. We investigated the binding and volumetric properties of DB1976, a model bis(benzimidazole)-selenophene diamidine compound w...

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Détails bibliographiques
Publié dans:Biophys J
Auteurs principaux: Ha, Van L.T., Erlitzki, Noa, Farahat, Abdelbasset A., Kumar, Arvind, Boykin, David W., Poon, Gregory M.K.
Format: Artigo
Langue:Inglês
Publié: The Biophysical Society 2020
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7567977/
https://ncbi.nlm.nih.gov/pubmed/32898478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2020.08.013
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