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Synthesis and Inhibitory Studies of Phosphonic Acid Analogues of Homophenylalanine and Phenylalanine towards Alanyl Aminopeptidases

A library of novel phosphonic acid analogues of homophenylalanine and phenylalanine, containing fluorine and bromine atoms in the phenyl ring, have been synthesized. Their inhibitory properties against two important alanine aminopeptidases, of human (hAPN, CD13) and porcine (pAPN) origin, were evalu...

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Pubblicato in:Biomolecules
Autori principali: Wanat, Weronika, Talma, Michał, Dziuk, Błażej, Kafarski, Paweł
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7565091/
https://ncbi.nlm.nih.gov/pubmed/32938014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10091319
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