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Phosphonic Acid Analogs of Fluorophenylalanines as Inhibitors of Human and Porcine Aminopeptidases N: Validation of the Importance of the Substitution of the Aromatic Ring

A library of phosphonic acid analogs of phenylalanine substituted with fluorine, chlorine and trifluoromethyl moieties on the aromatic ring was synthesized and evaluated for inhibitory activity against human (hAPN) and porcine (pAPN) aminopeptidases. Fluorogenic screening indicated that these analog...

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Библиографические подробности
Опубликовано в: :Biomolecules
Главные авторы: Wanat, Weronika, Talma, Michał, Dziuk, Błażej, Pirat, Jean-Luc, Kafarski, Paweł
Формат: Artigo
Язык:Inglês
Опубликовано: MDPI 2020
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7226027/
https://ncbi.nlm.nih.gov/pubmed/32283833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10040579
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