Phosphonic Acid Analogs of Fluorophenylalanines as Inhibitors of Human and Porcine Aminopeptidases N: Validation of the Importance of the Substitution of the Aromatic Ring

A library of phosphonic acid analogs of phenylalanine substituted with fluorine, chlorine and trifluoromethyl moieties on the aromatic ring was synthesized and evaluated for inhibitory activity against human (hAPN) and porcine (pAPN) aminopeptidases. Fluorogenic screening indicated that these analog...

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Bibliografiska uppgifter
I publikationen:Biomolecules
Huvudupphovsmän: Wanat, Weronika, Talma, Michał, Dziuk, Błażej, Pirat, Jean-Luc, Kafarski, Paweł
Materialtyp: Artigo
Språk:Inglês
Publicerad: MDPI 2020
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7226027/
https://ncbi.nlm.nih.gov/pubmed/32283833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10040579
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