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Phosphonic Acid Analogs of Fluorophenylalanines as Inhibitors of Human and Porcine Aminopeptidases N: Validation of the Importance of the Substitution of the Aromatic Ring

A library of phosphonic acid analogs of phenylalanine substituted with fluorine, chlorine and trifluoromethyl moieties on the aromatic ring was synthesized and evaluated for inhibitory activity against human (hAPN) and porcine (pAPN) aminopeptidases. Fluorogenic screening indicated that these analog...

詳細記述

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書誌詳細
出版年:Biomolecules
主要な著者: Wanat, Weronika, Talma, Michał, Dziuk, Błażej, Pirat, Jean-Luc, Kafarski, Paweł
フォーマット: Artigo
言語:Inglês
出版事項: MDPI 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7226027/
https://ncbi.nlm.nih.gov/pubmed/32283833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10040579
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