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FRET-Based Sorting of Live Cells Reveals Shifted Balance between PLK1 and CDK1 Activities During Checkpoint Recovery

Cells recovering from the G2/M DNA damage checkpoint rely more on Aurora A-PLK1 signaling than cells progressing through an unperturbed G2 phase, but the reason for this discrepancy is not known. Here, we devised a method based on a FRET reporter for PLK1 activity to sort cells in distinct populatio...

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Detalhes bibliográficos
Publicado no:Cells
Main Authors: Lafranchi, Lorenzo, Müllers, Erik, Rutishauser, Dorothea, Lindqvist, Arne
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7564076/
https://ncbi.nlm.nih.gov/pubmed/32961751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9092126
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