An Underlying Mechanism of Dual Wnt Inhibition and AMPK Activation: Mitochondrial Uncouplers Masquerading as Wnt Inhibitors

The importance of upregulated Wnt signaling in colorectal cancers led to efforts to develop inhibitors that target β-catenin in this pathway. We now report that several “Wnt inhibitors” that allegedly target β-catenin actually function as mitochondrial proton uncouplers that independently activate A...

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Publicat a:J Med Chem
Autors principals: Zhang, Wen, Sviripa, Vitaliy M., Kril, Liliia M., Yu, Tianxin, Xie, Yanqi, Hubbard, W. Brad, Sullivan, Patrick G., Chen, Xi, Zhan, Chang-Guo, Yang-Hartwich, Yang, Evers, B. Mark, Spear, Brett T., Gedaly, Roberto, Watt, David S., Liu, Chunming
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7560992/
https://ncbi.nlm.nih.gov/pubmed/31774672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b01685
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