An Underlying Mechanism of Dual Wnt Inhibition and AMPK Activation: Mitochondrial Uncouplers Masquerading as Wnt Inhibitors

The importance of upregulated Wnt signaling in colorectal cancers led to efforts to develop inhibitors that target β-catenin in this pathway. We now report that several “Wnt inhibitors” that allegedly target β-catenin actually function as mitochondrial proton uncouplers that independently activate A...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:J Med Chem
Main Authors: Zhang, Wen, Sviripa, Vitaliy M., Kril, Liliia M., Yu, Tianxin, Xie, Yanqi, Hubbard, W. Brad, Sullivan, Patrick G., Chen, Xi, Zhan, Chang-Guo, Yang-Hartwich, Yang, Evers, B. Mark, Spear, Brett T., Gedaly, Roberto, Watt, David S., Liu, Chunming
Formato: Artigo
Idioma:Inglês
Publicado: 2019
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7560992/
https://ncbi.nlm.nih.gov/pubmed/31774672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b01685
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares