Phenylethynyl-substituted heterocycles inhibit cyclin D1 and induce the expression of cyclin-dependent kinase inhibitor p21(Wif1/Cip1) in colorectal cancer cells

Fluorinated phenylethynyl-substituted heterocycles that possessed either an N-methylamino or N,N-dimethylamino group attached to heterocycles including pyridines, indoles, 1H-indazoles, quinolines, and isoquinolines inhibited the proliferation of LS174T colon cancer cells in which the inhibition of...

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Detalhes bibliográficos
Publicado no:Medchemcomm
Main Authors: Sviripa, Vitaliy M., Kril, Liliia M., Zhang, Wen, Xie, Yanqi, Wyrebek, Przemyslaw, Ponomareva, Larissa, Liu, Xifu, Yuan, Yaxia, Zhan, Chang-Guo, Watt, David S., Liu, Chunming
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2017
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5839514/
https://ncbi.nlm.nih.gov/pubmed/29527286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7md00393e
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