Epigenetic Regulation of Wnt Signaling by Carboxamide-Substituted Benzhydryl Amines that Function as Histone Demethylase Inhibitors

Aberrant activation of Wnt signaling triggered by mutations in either Adenomatous Polyposis Coli (APC) or CTNNB1 (β-catenin) is a hallmark of colorectal cancers (CRC). As part of a program to develop epigenetic regulators for cancer therapy, we developed carboxamide-substituted benzhydryl amines (CB...

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Publicado no:iScience
Main Authors: Zhang, Wen, Sviripa, Vitaliy M., Xie, Yanqi, Yu, Tianxin, Haney, Meghan G., Blackburn, Jessica S., Adeniran, Charles A., Zhan, Chang-Guo, Watt, David S., Liu, Chunming
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7718485/
https://ncbi.nlm.nih.gov/pubmed/33305174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101795
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