N-Aryl Benzenesulfonamide Inhibitors of [(3)H]-Thymidine Incorporation and β-Catenin Signaling in Human Hepatocyte-derived Huh-7 Carcinoma Cells

Structure-activity relationships (SAR) in 2,5-dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide (FH535) were examined as part of a program to identify agents that inhibit the Wnt/β-catenin signaling pathway that is frequently upregulated in hepatocellular carcinoma (HCC). FH535 was reported as a...

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Udgivet i:Bioorg Med Chem Lett
Main Authors: Kril, Liliia M., Vilchez, Valery, Jiang, Jieyun, Turcios, Lilia, Chen, Changguo, Sviripa, Vitaliy M., Zhang, Wen, Liu, Chunming, Spear, Brett, Watt, David S., Gedaly, Roberto
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4540627/
https://ncbi.nlm.nih.gov/pubmed/26243371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.07.040
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