Stress-induced TRAILR2 expression overcomes TRAIL resistance in cancer cell spheroids

The influence of 3D microenvironments on apoptosis susceptibility remains poorly understood. Here, we studied the susceptibility of cancer cell spheroids, grown to the size of micrometastases, to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Interestingly, pronounced, spatially co...

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Vydáno v:Cell Death Differ
Hlavní autoři: Stöhr, Daniela, Schmid, Jens O., Beigl, Tobias B., Mack, Alexandra, Maichl, Daniela S., Cao, Kai, Budai, Beate, Fullstone, Gavin, Kontermann, Roland E., Mürdter, Thomas E., Tait, Stephen W. G., Hagenlocher, Cathrin, Pollak, Nadine, Scheurich, Peter, Rehm, Markus
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7560834/
https://ncbi.nlm.nih.gov/pubmed/32433558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-0559-3
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