CD70-restricted specific activation of TRAILR1 or TRAILR2 using scFv-targeted TRAIL mutants

To combine the CD27 stimulation inhibitory effect of blocking CD70 antibodies with an antibody-dependent cellular cytotoxicity (ADCC)-independent, cell death-inducing activity for targeting of CD70-expressing tumors, we evaluated here fusion proteins of the apoptosis-inducing TNF family member TRAIL...

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Bibliografiske detaljer
Main Authors: Trebing, J, El-Mesery, M, Schäfer, V, Weisenberger, D, Siegmund, D, Silence, K, Wajant, H
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2014
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040681/
https://ncbi.nlm.nih.gov/pubmed/24481449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.555
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