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CD70-restricted specific activation of TRAILR1 or TRAILR2 using scFv-targeted TRAIL mutants
To combine the CD27 stimulation inhibitory effect of blocking CD70 antibodies with an antibody-dependent cellular cytotoxicity (ADCC)-independent, cell death-inducing activity for targeting of CD70-expressing tumors, we evaluated here fusion proteins of the apoptosis-inducing TNF family member TRAIL...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4040681/ https://ncbi.nlm.nih.gov/pubmed/24481449 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.555 |
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