Stress-induced TRAILR2 expression overcomes TRAIL resistance in cancer cell spheroids

The influence of 3D microenvironments on apoptosis susceptibility remains poorly understood. Here, we studied the susceptibility of cancer cell spheroids, grown to the size of micrometastases, to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Interestingly, pronounced, spatially co...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Stöhr, Daniela, Schmid, Jens O., Beigl, Tobias B., Mack, Alexandra, Maichl, Daniela S., Cao, Kai, Budai, Beate, Fullstone, Gavin, Kontermann, Roland E., Mürdter, Thomas E., Tait, Stephen W. G., Hagenlocher, Cathrin, Pollak, Nadine, Scheurich, Peter, Rehm, Markus
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7560834/
https://ncbi.nlm.nih.gov/pubmed/32433558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-0559-3
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