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Beclin 1 functions as a negative modulator of MLKL oligomerisation by integrating into the necrosome complex

Necroptosis is a form of regulated cell death caused by formation of the necrosome complex. However, the factors modulating this process and the systemic pathophysiological effects of necroptosis are yet to be understood. Here, we identified that Beclin 1 functions as an anti-necroptosis factor by b...

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Bibliographische Detailangaben
Veröffentlicht in:Cell Death Differ
Hauptverfasser: Seo, Jinho, Seong, Daehyeon, Nam, Young Woo, Hwang, Chi Hyun, Lee, Seung Ri, Lee, Choong-Sil, Jin, Young, Lee, Han-Woong, Oh, Doo-Byoung, Vandenabeele, Peter, Song, Jaewhan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7560833/
https://ncbi.nlm.nih.gov/pubmed/32457484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-0561-9
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