The brace helices of MLKL mediate interdomain communication and oligomerisation to regulate cell death by necroptosis

The programmed cell death pathway, necroptosis, relies on the pseudokinase, Mixed Lineage Kinase domain-Like (MLKL), for cellular execution downstream of death receptor or Toll-like receptor ligation. Receptor-interacting protein kinase-3 (RIPK3)-mediated phosphorylation of MLKL’s pseudokinase domai...

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Udgivet i:Cell Death Differ
Main Authors: Davies, Katherine A., Tanzer, Maria C., Griffin, Michael D. W., Mok, Yee Foong, Young, Samuel N., Qin, Rui, Petrie, Emma J., Czabotar, Peter E., Silke, John, Murphy, James M.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6143630/
https://ncbi.nlm.nih.gov/pubmed/29445128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-018-0061-3
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