Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis

Necroptotic cell death is mediated by the most terminal known effector of the pathway, MLKL. Precisely how phosphorylation of the MLKL pseudokinase domain activation loop by the upstream kinase, RIPK3, induces unmasking of the N-terminal executioner four-helix bundle (4HB) domain of MLKL, higher-ord...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Petrie, Emma J., Sandow, Jarrod J., Jacobsen, Annette V., Smith, Brian J., Griffin, Michael D. W., Lucet, Isabelle S., Dai, Weiwen, Young, Samuel N., Tanzer, Maria C., Wardak, Ahmad, Liang, Lung-Yu, Cowan, Angus D., Hildebrand, Joanne M., Kersten, Wilhelmus J. A., Lessene, Guillaume, Silke, John, Czabotar, Peter E., Webb, Andrew I., Murphy, James M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6013482/
https://ncbi.nlm.nih.gov/pubmed/29930286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04714-7
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados