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Flicking the molecular switch underlying MLKL-mediated necroptosis
The pseudokinase domain of the necroptosis effector mixed lineage kinase domain-like (MLKL) functions as a latch to restrain the unleashing of its N-terminal 4-helix bundle (4HB) domain. Cell death mediated by the 4HB domain relies on membrane association and oligomerization, which can be inhibited...
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| Udgivet i: | Mol Cell Oncol |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Taylor & Francis
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4905300/ https://ncbi.nlm.nih.gov/pubmed/27308464 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/23723556.2014.985550 |
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