Evolutionary divergence of the necroptosis effector MLKL

The pseudokinase, MLKL (mixed-lineage kinase domain-like), is the most terminal obligatory component of the necroptosis cell death pathway known. Phosphorylation of the MLKL pseudokinase domain by the protein kinase, receptor interacting protein kinase-3 (RIPK3), is known to be the key step in MLKL...

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Bibliografiske detaljer
Udgivet i:Cell Death Differ
Main Authors: Tanzer, M C, Matti, I, Hildebrand, J M, Young, S N, Wardak, A, Tripaydonis, A, Petrie, E J, Mildenhall, A L, Vaux, D L, Vince, J E, Czabotar, P E, Silke, J, Murphy, J M
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Original Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4946887/
https://ncbi.nlm.nih.gov/pubmed/26868910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2015.169
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