HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death

Necroptosis is a caspase-independent form of regulated cell death that has been implicated in the development of a range of inflammatory, autoimmune and neurodegenerative diseases. The pseudokinase, Mixed Lineage Kinase Domain-Like (MLKL), is the most terminal known obligatory effector in the necrop...

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Bibliografiske detaljer
Udgivet i:Cell Death Dis
Main Authors: Jacobsen, A V, Lowes, K N, Tanzer, M C, Lucet, I S, Hildebrand, J M, Petrie, E J, van Delft, M F, Liu, Z, Conos, S A, Zhang, J-G, Huang, D C S, Silke, J, Lessene, G, Murphy, J M
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816171/
https://ncbi.nlm.nih.gov/pubmed/26775703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.386
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