Hsp90 modulates the stability of MLKL and is required for TNF-induced necroptosis

The pseudokinase mixed lineage kinase domain-like protein (MLKL) is a key component of tumor necrosis factor (TNF)-induced necroptosis and plays a crucial role in necroptosis execution. However, the mechanisms that control MLKL activity are not completely understood. Here, we identify the molecular...

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Bibliografiske detaljer
Udgivet i:Cell Death Dis
Main Authors: Zhao, X M, Chen, Z, Zhao, J B, Zhang, P P, Pu, Y F, Jiang, S H, Hou, J J, Cui, Y M, Jia, X L, Zhang, S Q
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4849146/
https://ncbi.nlm.nih.gov/pubmed/26866270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.390
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