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V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitors
The Raf family includes three members, of which B-Raf is frequently mutated in melanoma and other tumors. We show that Raf-1 and A-Raf require Hsp90 for stability, whereas B-Raf does not. In contrast, mutated, activated B-Raf binds to an Hsp90–cdc37 complex, which is required for its stability and f...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1325013/ https://ncbi.nlm.nih.gov/pubmed/16371460 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609973103 |
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