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Nuclear RIPK3 and MLKL contribute to cytosolic necrosome formation and necroptosis

Necroptotic signaling converges in the assembly of a cytosolic signaling platform, the necrosome, with the activation of its downstream effector, MLKL. RIPK1 and RIPK3, key components of the necrosome, act as signaling intermediates for the activation of MLKL. We report that RIPK3 and MLKL continuou...

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Foilsithe in:Commun Biol
Main Authors: Weber, Kathrin, Roelandt, Ria, Bruggeman, Inge, Estornes, Yann, Vandenabeele, Peter
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2018
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6123744/
https://ncbi.nlm.nih.gov/pubmed/30271893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-017-0007-1
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