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Nuclear RIPK3 and MLKL contribute to cytosolic necrosome formation and necroptosis
Necroptotic signaling converges in the assembly of a cytosolic signaling platform, the necrosome, with the activation of its downstream effector, MLKL. RIPK1 and RIPK3, key components of the necrosome, act as signaling intermediates for the activation of MLKL. We report that RIPK3 and MLKL continuou...
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| Publicado no: | Commun Biol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6123744/ https://ncbi.nlm.nih.gov/pubmed/30271893 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-017-0007-1 |
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