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Nuclear RIPK3 and MLKL contribute to cytosolic necrosome formation and necroptosis
Necroptotic signaling converges in the assembly of a cytosolic signaling platform, the necrosome, with the activation of its downstream effector, MLKL. RIPK1 and RIPK3, key components of the necrosome, act as signaling intermediates for the activation of MLKL. We report that RIPK3 and MLKL continuou...
Sparad:
| I publikationen: | Commun Biol |
|---|---|
| Huvudupphovsmän: | , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Nature Publishing Group UK
2018
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6123744/ https://ncbi.nlm.nih.gov/pubmed/30271893 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-017-0007-1 |
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