Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis

Crystals cause injury in numerous disorders, and induce inflammation via the NLRP3 inflammasome, however, it remains unclear how crystals induce cell death. Here we report that crystals of calcium oxalate, monosodium urate, calcium pyrophosphate dihydrate and cystine trigger caspase-independent cell...

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Publicado no:Nat Commun
Main Authors: Mulay, Shrikant R., Desai, Jyaysi, Kumar, Santhosh V., Eberhard, Jonathan N., Thomasova, Dana, Romoli, Simone, Grigorescu, Melissa, Kulkarni, Onkar P., Popper, Bastian, Vielhauer, Volker, Zuchtriegel, Gabriele, Reichel, Christoph, Bräsen, Jan Hinrich, Romagnani, Paola, Bilyy, Rostyslav, Munoz, Luis E., Herrmann, Martin, Liapis, Helen, Krautwald, Stefan, Linkermann, Andreas, Anders, Hans-Joachim
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4738349/
https://ncbi.nlm.nih.gov/pubmed/26817517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10274
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