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Indoline-6-Sulfonamide Inhibitors of the Bacterial Enzyme DapE
Inhibitors of the bacterial enzyme dapE-encoded N-succinyl-l,l-diaminopimelic acid desuccinylase (DapE; EC 3.5.1.18) hold promise as antibiotics with a new mechanism of action. Herein we describe the discovery of a new series of indoline sulfonamide DapE inhibitors from a high-throughput screen and...
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| 出版年: | Antibiotics (Basel) |
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| 主要な著者: | , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
MDPI
2020
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7560015/ https://ncbi.nlm.nih.gov/pubmed/32933028 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antibiotics9090595 |
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