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Indoline-6-Sulfonamide Inhibitors of the Bacterial Enzyme DapE

Inhibitors of the bacterial enzyme dapE-encoded N-succinyl-l,l-diaminopimelic acid desuccinylase (DapE; EC 3.5.1.18) hold promise as antibiotics with a new mechanism of action. Herein we describe the discovery of a new series of indoline sulfonamide DapE inhibitors from a high-throughput screen and...

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Publicat a:Antibiotics (Basel)
Autors principals: Reidl, Cory T., Heath, Tahirah K., Darwish, Iman, Torrez, Rachel M., Moore, Maxwell, Gild, Elliot, Nocek, Boguslaw P., Starus, Anna, Holz, Richard C., Becker, Daniel P.
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7560015/
https://ncbi.nlm.nih.gov/pubmed/32933028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antibiotics9090595
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