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Tyrosine-Modification of Polypropylenimine (PPI) and Polyethylenimine (PEI) Strongly Improves Efficacy of siRNA-Mediated Gene Knockdown

The delivery of small interfering RNAs (siRNA) is an efficient method for gene silencing through the induction of RNA interference (RNAi). It critically relies, however, on efficient vehicles for siRNA formulation, for transfection in vitro as well as for their potential use in vivo. While polyethyl...

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Detalhes bibliográficos
Publicado no:Nanomaterials (Basel)
Main Authors: Noske, Sandra, Karimov, Michael, Aigner, Achim, Ewe, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7557430/
https://ncbi.nlm.nih.gov/pubmed/32927826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/nano10091809
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