Nose-to-brain siRNA delivery by PEI/PPI-based nanoparticles reduces α-synuclein expression in a Parkinson’s disease mouse model

Potential strategies to develop new treatments for Parkinson’s disease (PD) aim at targeting disease-associated proteins like alpha-synuclein (aSyn), which accumulates in neurons of PD patients and contributes to neuronal degeneration. A promising new approach is the therapeutic use of small interfe...

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Autores principales:	Malte Feja, Isabell Drath, Sandra Weiß, Alexander Ewe, Birthe Gericke, Tiago F. Outeiro, Leonidas Stefanis, Achim Aigner, Franziska Richter
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2025-09-01
Colección:	Molecular Therapy: Nucleic Acids
Materias:	MT: Delivery Strategies intranasal in vivo siRNA delivery polyethylenimine polypropylenimine RNA interference
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S2162253125002252
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