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Cryo-EM analysis of PIP(2) regulation in mammalian GIRK channels
G-protein-gated inward rectifier potassium (GIRK) channels are regulated by G proteins and PIP(2). Here, using cryo-EM single particle analysis we describe the equilibrium ensemble of structures of neuronal GIRK2 as a function of the C8-PIP(2) concentration. We find that PIP(2) shifts the equilibriu...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7556866/ https://ncbi.nlm.nih.gov/pubmed/32844743 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.60552 |
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