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Molecular basis of signaling specificity between GIRK channels and GPCRs
Stimulated muscarinic acetylcholine receptors (M2Rs) release Gβγ subunits, which slow heart rate by activating a G protein-gated K(+) channel (GIRK). Stimulated β2 adrenergic receptors (β2ARs) also release Gβγ subunits, but GIRK is not activated. This study addresses the mechanism underlying this sp...
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| 出版年: | eLife |
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| 主要な著者: | , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
eLife Sciences Publications, Ltd
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6335053/ https://ncbi.nlm.nih.gov/pubmed/30526853 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.42908 |
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