β(2)-AR blockade potentiates MEK1/2 inhibitor effect on HNSCC by regulating the Nrf2-mediated defense mechanism

The β2-Adrenergic receptor (β2-AR) is a G protein-coupled receptor (GPCR), involved in the development of many cancers, among which HNSCC. In this contest, β2-AR signaling interacts with different pathways, such as PI3K and MAPK, commonly activated by TK receptors. For this reason, TK blockade is on...

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Udgivet i:Cell Death Dis
Main Authors: Mele, Luigi, Del Vecchio, Vitale, Marampon, Francesco, Regad, Tarik, Wagner, Sarah, Mosca, Laura, Bimonte, Sabrina, Giudice, Aldo, Liccardo, Davide, Prisco, Claudia, Schwerdtfeger, Melanie, La Noce, Marcella, Tirino, Virginia, Caraglia, Michele, Papaccio, Gianpaolo, Desiderio, Vincenzo, Barbieri, Antonio
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7555890/
https://ncbi.nlm.nih.gov/pubmed/33051434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-03056-x
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