HDAC2 depletion promotes osteosarcoma’s stemness both in vitro and in vivo: a study on a putative new target for CSCs directed therapy

BACKGROUND: Cancer stem cells (CSCs) play a key role in cancer initiation, progression and chemoresistance. Epigenetic alterations have been identified as prominent factors that contribute to the CSCs phenotype. Here, we investigated the effects of the HDAC inhibitor valproic acid (VPA) and the deme...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Exp Clin Cancer Res
Main Authors: La Noce, Marcella, Paino, Francesca, Mele, Luigi, Papaccio, Gianpaolo, Regad, Tarik, Lombardi, Angela, Papaccio, Federica, Desiderio, Vincenzo, Tirino, Virginia
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2018
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6276256/
https://ncbi.nlm.nih.gov/pubmed/30509303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0978-x
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