HDAC2 depletion promotes osteosarcoma’s stemness both in vitro and in vivo: a study on a putative new target for CSCs directed therapy

BACKGROUND: Cancer stem cells (CSCs) play a key role in cancer initiation, progression and chemoresistance. Epigenetic alterations have been identified as prominent factors that contribute to the CSCs phenotype. Here, we investigated the effects of the HDAC inhibitor valproic acid (VPA) and the deme...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Exp Clin Cancer Res
Päätekijät: La Noce, Marcella, Paino, Francesca, Mele, Luigi, Papaccio, Gianpaolo, Regad, Tarik, Lombardi, Angela, Papaccio, Federica, Desiderio, Vincenzo, Tirino, Virginia
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BioMed Central 2018
Aiheet:
Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6276256/
https://ncbi.nlm.nih.gov/pubmed/30509303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0978-x
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