HDAC2 depletion promotes osteosarcoma’s stemness both in vitro and in vivo: a study on a putative new target for CSCs directed therapy

BACKGROUND: Cancer stem cells (CSCs) play a key role in cancer initiation, progression and chemoresistance. Epigenetic alterations have been identified as prominent factors that contribute to the CSCs phenotype. Here, we investigated the effects of the HDAC inhibitor valproic acid (VPA) and the deme...

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Библиографические подробности
Опубликовано в: :J Exp Clin Cancer Res
Главные авторы: La Noce, Marcella, Paino, Francesca, Mele, Luigi, Papaccio, Gianpaolo, Regad, Tarik, Lombardi, Angela, Papaccio, Federica, Desiderio, Vincenzo, Tirino, Virginia
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2018
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6276256/
https://ncbi.nlm.nih.gov/pubmed/30509303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0978-x
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