HDAC2 depletion promotes osteosarcoma’s stemness both in vitro and in vivo: a study on a putative new target for CSCs directed therapy

BACKGROUND: Cancer stem cells (CSCs) play a key role in cancer initiation, progression and chemoresistance. Epigenetic alterations have been identified as prominent factors that contribute to the CSCs phenotype. Here, we investigated the effects of the HDAC inhibitor valproic acid (VPA) and the deme...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: La Noce, Marcella, Paino, Francesca, Mele, Luigi, Papaccio, Gianpaolo, Regad, Tarik, Lombardi, Angela, Papaccio, Federica, Desiderio, Vincenzo, Tirino, Virginia
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6276256/
https://ncbi.nlm.nih.gov/pubmed/30509303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0978-x
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