Glucose-6-phosphate dehydrogenase blockade potentiates tyrosine kinase inhibitor effect on breast cancer cells through autophagy perturbation

BACKGROUND: Glucose-6-phospate dehydrogenase (G6PD) is the limiting enzyme of the pentose phosphate pathway (PPP) correlated to cancer progression and drug resistance. We previously showed that G6PD inhibition leads to Endoplasmic Reticulum (ER) stress often associated to autophagy deregulation. The...

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Bibliografiske detaljer
Udgivet i:J Exp Clin Cancer Res
Main Authors: Mele, Luigi, la Noce, Marcella, Paino, Francesca, Regad, Tarik, Wagner, Sarah, Liccardo, Davide, Papaccio, Gianpaolo, Lombardi, Angela, Caraglia, Michele, Tirino, Virginia, Desiderio, Vincenzo, Papaccio, Federica
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6466760/
https://ncbi.nlm.nih.gov/pubmed/30987650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1164-5
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