Glucose-6-phosphate dehydrogenase blockade potentiates tyrosine kinase inhibitor effect on breast cancer cells through autophagy perturbation

BACKGROUND: Glucose-6-phospate dehydrogenase (G6PD) is the limiting enzyme of the pentose phosphate pathway (PPP) correlated to cancer progression and drug resistance. We previously showed that G6PD inhibition leads to Endoplasmic Reticulum (ER) stress often associated to autophagy deregulation. The...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Mele, Luigi, la Noce, Marcella, Paino, Francesca, Regad, Tarik, Wagner, Sarah, Liccardo, Davide, Papaccio, Gianpaolo, Lombardi, Angela, Caraglia, Michele, Tirino, Virginia, Desiderio, Vincenzo, Papaccio, Federica
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6466760/
https://ncbi.nlm.nih.gov/pubmed/30987650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1164-5
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