β(2)-AR blockade potentiates MEK1/2 inhibitor effect on HNSCC by regulating the Nrf2-mediated defense mechanism

The β2-Adrenergic receptor (β2-AR) is a G protein-coupled receptor (GPCR), involved in the development of many cancers, among which HNSCC. In this contest, β2-AR signaling interacts with different pathways, such as PI3K and MAPK, commonly activated by TK receptors. For this reason, TK blockade is on...

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Gepubliceerd in:Cell Death Dis
Hoofdauteurs: Mele, Luigi, Del Vecchio, Vitale, Marampon, Francesco, Regad, Tarik, Wagner, Sarah, Mosca, Laura, Bimonte, Sabrina, Giudice, Aldo, Liccardo, Davide, Prisco, Claudia, Schwerdtfeger, Melanie, La Noce, Marcella, Tirino, Virginia, Caraglia, Michele, Papaccio, Gianpaolo, Desiderio, Vincenzo, Barbieri, Antonio
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7555890/
https://ncbi.nlm.nih.gov/pubmed/33051434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-03056-x
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