β(2)-AR blockade potentiates MEK1/2 inhibitor effect on HNSCC by regulating the Nrf2-mediated defense mechanism

The β2-Adrenergic receptor (β2-AR) is a G protein-coupled receptor (GPCR), involved in the development of many cancers, among which HNSCC. In this contest, β2-AR signaling interacts with different pathways, such as PI3K and MAPK, commonly activated by TK receptors. For this reason, TK blockade is on...

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Detaylı Bibliyografya
Yayımlandı:Cell Death Dis
Asıl Yazarlar: Mele, Luigi, Del Vecchio, Vitale, Marampon, Francesco, Regad, Tarik, Wagner, Sarah, Mosca, Laura, Bimonte, Sabrina, Giudice, Aldo, Liccardo, Davide, Prisco, Claudia, Schwerdtfeger, Melanie, La Noce, Marcella, Tirino, Virginia, Caraglia, Michele, Papaccio, Gianpaolo, Desiderio, Vincenzo, Barbieri, Antonio
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7555890/
https://ncbi.nlm.nih.gov/pubmed/33051434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-03056-x
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